Compartmentalized biosynthesis of fungal natural products

Fungal natural products (NPs) with diverse chemical structures and biological activities are rich resources of both drugs and toxins, thus causing Janus-like effects on human beings. Significant progress has been made in discovery and mining of novel fungal NPs in the past decades. Unlike prokaryotic organisms, eukaryotic cells of fungi have discrete organelles to form compartmentalized assembly lines for the highly ordered and hence efficient biosynthesis of fungal NPs. In this review, we summarize a limited but growing number of studies on compartmentalized biosynthesis of fungal NPs. The emerging strategies and efforts for engineering of subcellular localization of relevant biosynthetic enzymes are also discussed. We expect to provide some new insights and perspectives on the more complex NP biogenesis in higher microorganisms.