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Astrocytic cAMP modulates memory via synaptic plasticity.

Zhiwen Zhou1, Kazuki Okamoto1, Junya Onodera1

  • 1Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, 113-8654 Tokyo, Japan.

Proceedings of the National Academy of Sciences of the United States of America
|January 16, 2021
PubMed
Summary
This summary is machine-generated.

Increasing cyclic adenosine monophosphate (cAMP) in astrocytes enhances memory formation but impairs retention by altering synaptic plasticity and glial-neuronal interactions. This research offers a novel tool to study astrocyte function in vivo.

Keywords:
PACastrocytecAMPmemorysynapse

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Area of Science:

  • Neuroscience
  • Cellular Biology
  • Molecular Biology

Background:

  • Astrocytes are crucial for brain homeostasis and cognitive functions like memory.
  • Astrocytes utilize cyclic adenosine monophosphate (cAMP) as a second messenger.
  • The precise role of astrocytic cAMP in animal behavior and glial-neuronal communication is not well understood.

Purpose of the Study:

  • To investigate the impact of astrocytic cAMP on synaptic plasticity and memory.
  • To explore the underlying mechanisms of glial-neuronal interactions modulated by astrocytic cAMP.
  • To develop a method for manipulating astrocytic cAMP levels in vivo.

Main Methods:

  • Utilized a photoactivated adenylyl cyclase to selectively increase cAMP in hippocampal astrocytes in vivo.
  • Assessed memory formation and retention in animal models.
  • Investigated the role of NMDA receptor-dependent plasticity and the astrocyte-neuron lactate shuttle.

Main Results:

  • Elevated astrocytic cAMP levels facilitated memory formation.
  • Increased astrocytic cAMP impaired memory retention.
  • The observed memory modulation was dependent on NMDA receptor activity and the astrocyte-neuron lactate shuttle.

Conclusions:

  • Astrocytic cAMP plays a significant role in modulating memory processes.
  • Increased astrocytic cAMP influences synaptic plasticity and glial-neuronal communication.
  • This study provides a valuable tool for in vivo manipulation of astrocytic cAMP, advancing our understanding of astrocyte function in the brain.