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Sensing the future of bio-informational engineering.

Thomas A Dixon1, Thomas C Williams2,3, Isak S Pretorius4

  • 1Department of Modern History, Politics and International Relations, Macquarie University, Sydney, NSW, 2109, Australia. thom.dixon@mq.edu.au.

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Synthetic biology integrates organic and digital systems for novel bio-informational engineering applications. This advancement requires reimagining biological systems as cyber-physical architectures for future innovations.

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Area of Science:

  • Synthetic Biology and Bio-informational Engineering
  • Cyber-Physical Systems and Engineering Biology

Background:

  • Synthetic biology practices are merging with multiscale designs.
  • This integration enables bidirectional communication between organic and inorganic information substrates.
  • It spans biological, digital, and cyber-physical system integrations.

Purpose of the Study:

  • To explore novel applications of bio-informational engineering.
  • To propose a framework for understanding and developing integrated biological and digital systems.
  • To highlight the need for reimagining biological systems as cyber-physical architectures.

Main Methods:

  • Integration of synthetic biology principles with multiscale design concepts.
  • Exploration of communication pathways across diverse information substrates.
  • Conceptualization of biological systems as cyber-physical architectures.

Main Results:

  • Anticipation of novel applications in environmental monitoring, precision agriculture, medicine, and biomanufacturing.
  • Potential for developments such as sentinel plants and autonomous bioreactors.
  • Identification of the need for a multiscale taxonomy to guide future engineering biology.

Conclusions:

  • The convergence of synthetic biology and cyber-physical systems offers transformative potential.
  • A multiscale approach is crucial for rationalizing and advancing engineering biology.
  • Future biological and engineered systems will be understood as complex cyber-physical architectures.