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Related Experiment Video

Updated: Nov 21, 2025

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Regen Fat Code: A Standardized Protocol for Facial Volumetry and Rejuvenation.

Luiz Charles-de-Sá1, Natale Ferreira Gontijo-de-Amorim2, Sydney Coleman3

  • 1Department of Plastic, Reconstructive and Aesthetic Surgery, Training and Research State University Hospital of Rio de Janeiro, Rio de Janeiro, Brazil.

Aesthetic Surgery Journal
|January 16, 2021
PubMed
Summary

This study tested a new protocol called Regen Fat Code for facial rejuvenation using fat grafting. The protocol standardizes how fat is placed in the face to restore volume and improve contours. Eighty patients were split into two groups: one received only fat grafting, while the other added face-lifting. The study found that fat retention varied by facial region, with static areas like the malar region retaining more fat than dynamic ones. The authors suggest that the protocol could help surgeons achieve more predictable results. The findings may refine how facial rejuvenation is performed using fat grafting.

Keywords:
Facial Rejuvenation ProtocolStructural Fat GraftingFacial Aging TreatmentAesthetic Surgery Outcomes

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Area of Science:

  • Facial Plastic Surgery
  • Regenerative Medicine
  • Aesthetic Surgery Outcomes Research

Background:

Facial aging leads to volume loss and altered contours. Established knowledge shows that structural fat grafting can restore facial volume. However, inconsistencies in technique limit predictable results. Prior research has shown that fat grafting outcomes vary based on anatomical site and graft handling. No prior work had resolved a standardized protocol for facial volumetric analysis. This gap motivated the development of a new method. That uncertainty drove the need for a systematic approach. The Regen Fat Code protocol was created to address these limitations. This paper introduces a clinical trial to test the protocol's effectiveness.

Purpose Of The Study:

The study aimed to evaluate a new standardized protocol for facial volumetric rejuvenation. The protocol, called Regen Fat Code, integrates structural fat grafting with systematic volumetric analysis. The authors sought to determine if the protocol improves consistency in facial fat grafting. They tested the protocol in two surgical approaches. Group A received only fat grafting, while Group B added face-lifting. The goal was to assess graft absorption and volumetric outcomes. The researchers propose that standardization could enhance surgical predictability. This approach may refine facial rejuvenation techniques.

Main Methods:

The study involved 80 patients divided into two groups. Group A received structural fat grafting alone. Group B combined fat grafting with face-lifting. The Regen Fat Code protocol guided fat distribution. Three clinical tools were used for volumetric analysis. Fat volumes were measured in milliliters per anatomical zone. The nasolabial fold, lips, malar, and chin were targeted. Postoperative assessments tracked absorption rates. The study design allowed comparison of graft retention across regions.

Main Results:

Fat volumes ranged from 1 to 20 mL per patient. Malar areas received the highest volume at 8.51 mL on average. The inferior eyelid received the lowest at 1.2 mL. Static areas showed lower absorption than dynamic ones. Group A had consistent graft retention in malar regions. Group B showed similar outcomes with added face-lifting. The protocol enabled precise volume distribution. The study suggests that anatomical site affects graft survival.

Conclusions:

The Regen Fat Code protocol demonstrated potential for standardizing facial fat grafting. The authors propose that structured methods improve graft predictability. The protocol allows tailored volumetric approaches per surgical zone. No prior work had resolved such a systematic framework. The study suggests that static areas retain fat better than dynamic ones. The researchers propose that this protocol could enhance facial rejuvenation outcomes. The authors suggest further validation in larger cohorts. This approach may refine aesthetic surgery practices.

The Regen Fat Code is a standardized protocol for facial volumetric rejuvenation using structural fat grafting.

The protocol uses three clinical tools for pre- and postoperative volumetric analysis to guide fat placement.

The study suggests that static areas have lower absorption rates compared to dynamic facial regions.

Three clinical tools were used to assess facial volume before and after the procedure.

The average fat volume in the malar region was 8.51 mL with a standard deviation of 5.25 mL.

The authors propose that the Regen Fat Code protocol could improve consistency in facial fat grafting outcomes.