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Author Spotlight: Evaluation of Protein-Condensate Dynamics in Live Human Cells
Published on: January 5, 2024
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Quantifying viscosity and surface tension of multicomponent protein-nucleic acid condensates
Ibraheem Alshareedah1, George M Thurston2, Priya R Banerjee1
1Department of Physics, University at Buffalo SUNY, Buffalo, New York.
Biophysical Journal
|January 16, 2021
Summary
Nucleic acid (NA) levels control the surface tension of cellular condensates, not their internal viscosity or protein/NA diffusion. This impacts how cell condensate organization changes with composition.
Area of Science:
- Biochemistry
- Cell Biology
- Biophysics
Background:
- Cells form dynamic liquid condensates via liquid-liquid phase separation.
- Multivalent proteins and nucleic acids (NA) drive condensate formation.
- Understanding how stoichiometry affects condensate properties is crucial.
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