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Updated: Nov 21, 2025

Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
Challenge to overcome current limitations of cell-penetrating peptides
Gyu Chan Kim1, Dae Hee Cheon1, Yan Lee1
1Department of Chemistry, Seoul National University, Seoul 151-742, Republic of Korea.
Abstract:
The penetration of biological membranes is a prime obstacle for the delivery of pharmaceutical drugs. Cell-penetrating peptide (CPP) is an efficient vehicle that can deliver various cargos across the biological membranes. Since the discovery, CPPs have been rigorously studied to unveil the underlying penetrating mechanism as well as to exploit CPPs for various biomedical applications. This review will focus on the various strategies to overcome current limitations regarding stability, selectivity, and efficacy of CPPs.
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