Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hierarchy of Motor Control01:18

Hierarchy of Motor Control

5.2K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
5.2K
Motor Units00:46

Motor Units

61.1K
A motor unit consists of two main components: a single efferent motor neuron (i.e., a neuron that carries impulses away from the central nervous system) and all of the muscle fibers it innervates. The motor neuron may innervate multiple muscle fibers, which are single cells, but only one motor neuron innervates a single muscle fiber.
61.1K
Motor Units01:13

Motor Units

6.6K
The motor unit is a fundamental component of the neuromuscular system and plays a crucial role in coordinating muscle contractions. It consists of a somatic motor neuron, which connects and controls multiple skeletal muscle fibers, forming a single functional segment. The axon of the motor neuron branches out and establishes synaptic connections known as neuromuscular junctions with individual muscle fibers within the motor unit.
Motor units come in different sizes, with smaller units...
6.6K
Direct Motor Pathways01:11

Direct Motor Pathways

3.4K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
3.4K
Indirect Motor Pathways01:22

Indirect Motor Pathways

2.4K
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
2.4K
Motor Unit Stimulation01:20

Motor Unit Stimulation

3.2K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of antiseizure medication with lower amyloid and tau burden.

medRxiv : the preprint server for health sciences·2026
Same author

Maternal, Infant, Reproductive and Child Health in Cystic Fibrosis (MATRIARCH_CF): a prospective, observational study to evaluate pregnancy and parenthood in females with cystic fibrosis and health of the offspring in the CFTR-modulator era.

BMJ open respiratory research·2026
Same author

White matter microstructure fingerprint of cerebral small vessel disease.

Brain : a journal of neurology·2026
Same author

The Diagnostic Complexities of Cystic Fibrosis: When to Think of It and What to Do?

British journal of hospital medicine (London, England : 2005)·2026
Same author

Beta burst dynamics in the motor cortex are reshaped through sensorimotor refinement.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

International Delphi consensus recommendations for the follow-up of children born to people with CF and exposed to CFTR modulators in utero or through breastfeeding; endorsed by the European Cystic Fibrosis Society.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society·2026
Same journal

Spatial frequency channels implement a mental ruler in spatial vision.

NeuroImage·2026
Same journal

Exploring the Link Between Intravoxel Incoherent Motion Measured Brain Diffusivity During Wakefulness and Sleep Macrostructure in the Elderly.

NeuroImage·2026
Same journal

Closed-loop adaptation of transcranial magnetic stimulation intensity with electroencephalography feedback.

NeuroImage·2026
Same journal

Volumetric postmortem MRI of the medial temporal lobe in Alzheimer's disease and related disorders: methodological advances and implications for in vivo biomarker development.

NeuroImage·2026
Same journal

Neural responses to equity and inequity when receiving vicarious rewards for self and charity during adolescence.

NeuroImage·2026
Same journal

Cognitive Strategy-based neuromodulation optimizes neural communication to improve working memory.

NeuroImage·2026
See all related articles

Related Experiment Video

Updated: Nov 21, 2025

Estimation of Contact Regions Between Hands and Objects During Human Multi-Digit Grasping
09:41

Estimation of Contact Regions Between Hands and Objects During Human Multi-Digit Grasping

Published on: April 21, 2023

2.0K

Mapping grip force to motor networks.

Ladina Weitnauer1, Stefan Frisch2, Lester Melie-Garcia1

  • 1LREN, Department of clinical neurosciences - CHUV, University Lausanne, Switzerland.

Neuroimage
|January 17, 2021
PubMed
Summary
This summary is machine-generated.

This study reveals that grip force strength is linked to widespread brain networks, involving both cortical and subcortical areas. Lesion mapping in stroke patients helped identify these crucial brain networks for motor control.

Keywords:
Brain lesionGrip forceMagnetic resonance imagingMulti-parameter mappingRelaxometryStrokeStructural covarianceVoxel-based morphometryVoxel-based quantification

More Related Videos

Measurement of Spatial Stability in Precision Grip
09:36

Measurement of Spatial Stability in Precision Grip

Published on: June 4, 2020

3.4K
Rod-based Fabrication of Customizable Soft Robotic Pneumatic Gripper Devices for Delicate Tissue Manipulation
07:49

Rod-based Fabrication of Customizable Soft Robotic Pneumatic Gripper Devices for Delicate Tissue Manipulation

Published on: August 2, 2016

9.1K

Related Experiment Videos

Last Updated: Nov 21, 2025

Estimation of Contact Regions Between Hands and Objects During Human Multi-Digit Grasping
09:41

Estimation of Contact Regions Between Hands and Objects During Human Multi-Digit Grasping

Published on: April 21, 2023

2.0K
Measurement of Spatial Stability in Precision Grip
09:36

Measurement of Spatial Stability in Precision Grip

Published on: June 4, 2020

3.4K
Rod-based Fabrication of Customizable Soft Robotic Pneumatic Gripper Devices for Delicate Tissue Manipulation
07:49

Rod-based Fabrication of Customizable Soft Robotic Pneumatic Gripper Devices for Delicate Tissue Manipulation

Published on: August 2, 2016

9.1K

Area of Science:

  • Neuroscience
  • Motor Control
  • Brain Imaging

Background:

  • The precise roles of cortical and subcortical brain regions in modulating grip force remain debated.
  • Understanding the neural underpinnings of grip force is essential for diagnosing and treating motor deficits.

Purpose of the Study:

  • To investigate the anatomical basis of grip force using a whole-brain approach.
  • To explore interindividual differences in brain connectivity patterns related to grip force.
  • To leverage lesion mapping in patients with motor deficits to inform structural connectivity analysis in healthy individuals.

Main Methods:

  • Magnetic resonance imaging (MRI) and voxel-based morphometry were used in chronic stroke patients (n=55) and healthy controls (n=67).
  • Statistical parametric maps (SPMs) identified brain regions associated with grip force strength in grey and white matter.
  • These SPMs served as seed areas for whole-brain structural covariance analysis in a large cohort (n=977), assessing volume, myelin, iron, and water content.

Main Results:

  • Symmetrical bilateral clusters showed correlations between upper limb motor performance, basal ganglia, posterior insula, and the corticospinal tract.
  • Covariance analysis revealed widespread anatomical patterns in brain volume and tissue properties.
  • These patterns involved cortical and subcortical nodes of motor networks and sensorimotor projections.

Conclusions:

  • The findings suggest a biological signature of brain networks implicated in grip force control.
  • Overlapping structural covariance patterns were observed within cortico-subcortical motor networks across various tissue property estimates.
  • The results provide evidence for the biological plausibility and validity of these identified brain networks.