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Multicore myopathy: not always a benign entity
A Shuaib1, J M Martin, L B Mitchell
1Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Alberta, Canada.
Insights
Multicore Myopathy can progress to severe disability and is associated with cardiomyopathy. Cardiac involvement significantly worsens the prognosis for patients with this rare myopathy.
Area of Science:
- Neurology
- Cardiology
- Genetics
Background:
- Multicore Myopathy is a rare, morphologically distinct neuromuscular disorder.
- It was previously thought to be non-progressive or slowly progressive.
Observation:
- This study describes four patients diagnosed with Multicore Myopathy.
- Three of the four patients experienced progression to significant disability.
- All four patients presented with cardiomyopathy, a heart condition.
Findings:
- Multicore Myopathy can be a progressive condition, leading to substantial disability.
- Cardiac disease is a significant, previously underemphasized association with Multicore Myopathy.
- Heart disease was the cause of death in two of the study participants.
Implications:
- Multicore Myopathy is not always a benign condition.
- The presence of cardiac involvement negatively impacts the prognosis of Multicore Myopathy.
- Further research into the cardiac manifestations and management of Multicore Myopathy is warranted.
Abstract:
Four patients with Multicore Myopathy, a rare morphologically distinct myopathy, are described. Although previously considered to be a non-progressive or only slowly progressive myopathy, progression to significant disability was seen in three of our cases. The association of cardiac disease with Multicore Myopathy has not been previously emphasised. All four patients in this study had a cardiomyopathy, and heart disease was the cause of death in two of the patients. Multicore Myopathy is not always a benign entity. Cardiac involvement, when present, adversely affects prognosis.