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Multicore myopathy: not always a benign entity.

A Shuaib1, J M Martin, L B Mitchell

  • 1Department of Clinical Neurosciences, Faculty of Medicine, University of Calgary, Alberta, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
|February 1, 1988
PubMed
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Multicore Myopathy can progress to severe disability and is associated with cardiomyopathy. Cardiac involvement significantly worsens the prognosis for patients with this rare myopathy.

Area of Science:

  • Neurology
  • Cardiology
  • Genetics

Background:

  • Multicore Myopathy is a rare, morphologically distinct neuromuscular disorder.
  • It was previously thought to be non-progressive or slowly progressive.

Observation:

  • This study describes four patients diagnosed with Multicore Myopathy.
  • Three of the four patients experienced progression to significant disability.
  • All four patients presented with cardiomyopathy, a heart condition.

Findings:

  • Multicore Myopathy can be a progressive condition, leading to substantial disability.
  • Cardiac disease is a significant, previously underemphasized association with Multicore Myopathy.
  • Heart disease was the cause of death in two of the study participants.

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Implications:

  • Multicore Myopathy is not always a benign condition.
  • The presence of cardiac involvement negatively impacts the prognosis of Multicore Myopathy.
  • Further research into the cardiac manifestations and management of Multicore Myopathy is warranted.