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Updated: Nov 21, 2025
Utero-tubal Embryo Transfer and Vasectomy in the Mouse Model
Published on: February 28, 2014
ASSISTED REPRODUCTIVE TECHNOLOGY EFFICIENCY IMPROVEMENT OF TUBAL-PERITONEAL INFERTILITY
Victoria V Orlova1, Lidiia V Suslikova1, Olena A Orlova2
1SHUPYK NATIONAL MEDICAL ACADEMY OF POSTGRADUATE EDUCATION, UKRAINIAN STATE INSTITUTE OF REPRODUCTION, CLINIC OF REPRODUCTIVE TECHNOLOGIES, KYIV, UKRAINE.
Objective:
The aim: This study aims to develop and implement a complex of pregravid preparation based on endogenous melatonin level, development of oxidative stress and violation of apoptosis regulation in women with tubal-peritoneal infertility.
Patients And Methods:
Materials and methods: We have examined 100 women of reproductive age, including 65 women with tubal-peritoneal infertility treated by ART. All studied women were defined levels of endogenous melatonin, oxidative status and level of apoptosis in the endometrium and in follicular fluid (infertile women only). As a powerful free radical neutralizer, we used melatonin to improve the microenvironment of maturing oocytes and create favourable conditions for implantation in the endometrium.
Results:
Results: Treatment by exogenous melatonin showed better results than standard therapy without antioxidants: the quality of oocytes and embryos, the level of ongoing pregnancies and childbirth was significantly higher.
Conclusion:
Conclusions: We achieved such results due to restoring the balance in pro / antioxidant system and apoptosis in female reproductive tract.
