Related Experiment Video
Updated: Nov 21, 2025
Using 22C3 Anti-PD-L1 Antibody Concentrate on Biopsy and Cytology Samples from Non-small Cell Lung Cancer Patients
Published on: September 25, 2018
Penile Lymphoepithelioma-Like Carcinoma: A Rare Case With PD-L1 Expression
Raquel Machado-Neves1, Bernardo Teixeira2, Elsa Fonseca3,4
1Hospital Pedro Hispano, Matosinhos, Portugal.
This report details a rare human papillomavirus (HPV)-related penile cancer, lymphoepithelioma-like carcinoma (LELC). The case highlights tumor cells expressing PDL1, offering potential therapeutic insights for this uncommon malignancy.
Area of Science:
- Oncology
- Pathology
- Virology
Background:
- Penile squamous cell carcinoma (SCC) comprises HPV-related and non-HPV-related types.
- Lymphoepithelioma-like carcinoma (LELC) is a rare subtype of HPV-related penile SCC.
- Understanding rare penile cancers is crucial for diagnosis and treatment.
Observation:
- A 50-year-old male presented with testicular swelling and pain.
- A penile mass was identified, leading to a total penectomy.
- Microscopic examination revealed undifferentiated epithelial cells with lymphoplasmacytic infiltrate, consistent with LELC.
Findings:
- The LELC tumor cells expressed p16, a marker for HPV infection.
- Tumor cells also showed expression of PDL1 using three different clones (22C3, SP263, SP142).
- This is the third reported case of penile LELC and the first documenting PDL1 expression.
Implications:
- PDL1 expression in penile LELC may suggest potential response to immunotherapy.
- This case expands the understanding of rare penile malignancies.
- Further research into PDL1's role in penile LELC is warranted.
More Related Videos
10:29Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence
Published on: August 14, 2019
10:11Immunohistochemical Staining of B7-H1 PD-L1 on Paraffin-embedded Slides of Pancreatic Adenocarcinoma Tissue
Published on: January 3, 2013