Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

989
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
989
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.3K
Anatomy of the Intestines01:23

Anatomy of the Intestines

85.6K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
85.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single Immunoglobulin Interleukin1-Related Receptor-TWIST1 Axis Regulates Barrier Function in Neonatal Intestine.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Effects of polyphenolic compounds on the structure, allergenicity and gel properties of shrimp myofibrillar proteins.

Journal of the science of food and agriculture·2026
Same author

Integrated volatile profiling and metabolomics reveal changes in volatile compounds  during low-temperature smoking of sea bass (Lateolabrax maculatus).

Journal of the science of food and agriculture·2026
Same author

Phosphoproteomic and kinase networks reveal partial EMT and stress-adaptive growth programs in pediatric Peutz-Jeghers polyps.

Pediatric research·2026
Same author

An Emerging Approach to IBD Treatment: Personalized Nutrition Through Gut Microbiome Optimization.

Frontiers in bioscience (Landmark edition)·2026
Same author

Weight loss and omega-3 supplementation modulate the microbiome in women with increased breast cancer risk.

Cancer prevention research (Philadelphia, Pa.)·2026

Related Experiment Video

Updated: Nov 21, 2025

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

9.0K

Microbiome and Colorectal Cancer.

Ishfaq Ahmed1, Shahid Umar1

  • 1Department of Surgery and University of Kansas Cancer Center, University of Kansas Medical Center, Kansas City KS, USA.

Current Colorectal Cancer Reports
|January 18, 2021
PubMed
Summary

Altered gut microbiota is linked to colorectal cancer (CRC) development and progression. Understanding these microbial changes and their mechanisms is key for developing new CRC therapies.

Keywords:
Colorectal CancerDietGenotoxic bacteriaInflammationMetabolomeMicrobiomeOncomicrobes

More Related Videos

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.7K
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

7.2K

Related Experiment Videos

Last Updated: Nov 21, 2025

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

9.0K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.7K
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

7.2K

Area of Science:

  • Microbiome research
  • Gastroenterology
  • Oncology

Background:

  • The human body hosts trillions of microbes, collectively known as the human microbiota, which typically form a symbiotic relationship with the host.
  • Gut dysbiosis, an imbalance in microbial diversity, is increasingly implicated in the pathogenesis of gastrointestinal diseases, including colorectal cancer (CRC).

Purpose of the Study:

  • To review recent literature on alterations in gut microbiota composition and their influence on colorectal cancer (CRC) incidence and progression.
  • To explore the complex mechanisms linking gut microbes to CRC development.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of studies investigating gut microbiota composition in relation to CRC.
  • Examination of the 'driver-passenger' model of CRC development.

Main Results:

  • Evidence indicates distinct gut microbiota profiles in CRC patients compared to healthy individuals, with variations based on tumor location.
  • The 'driver-passenger' model proposes that specific bacteria induce inflammation and mutations, facilitating CRC progression.
  • Associations between individual bacterial species and consensus molecular subtypes (CMS) of CRC have been identified.

Conclusions:

  • A strong link exists between the intestinal microbiota and CRC development, though underlying mechanisms require further elucidation.
  • Mechanistic studies are needed to understand the interplay between diet, microbial communities, and metabolites in CRC evolution.
  • Therapeutic strategies targeting microbial associations with CMS hold promise for clinical translation in CRC and other cancers.