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Updated: Nov 21, 2025

Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy

Longitudinal Intravital Imaging of Brain Tumor Cell Behavior in Response to an Invasive Surgical Biopsy

Published on: May 3, 2019

A Simple Modified Technique for Frameless Brain Lesion Biopsy.

Sultan Al-Saiari¹, Ahmed A Farag¹, Khalid Al Orabi¹

¹Neurological Surgery, King Abdullah Medical City, Mecca, SAU.

|January 18, 2021

Summary

This study introduces a simple, reliable frameless technique for navigation-guided brain biopsy. The method enhances accuracy by maintaining stable instrument fixation, reducing operative time for brain tumor biopsies.

Keywords:

biopsy burr hole frameless navigation technique

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Last Updated: Nov 21, 2025

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Area of Science:

Neurosurgery
Medical Imaging
Surgical Navigation

Background:

Accurate target localization in image-guided surgery is crucial.
Instrument fixation and registration are key factors affecting navigation accuracy.
Disruption of fixation can lead to targeting inaccuracies in frameless procedures.

Purpose of the Study:

To evaluate the feasibility and reliability of a novel frameless technique for navigation-guided brain biopsy.
To demonstrate improvements in accuracy for frameless biopsy procedures.
To present a method that avoids repeated aiming device adjustments.

Main Methods:

Retrospective study of 10 patients undergoing navigation-guided brain biopsy (2018-2019).
Implementation of a simple frameless technique with fixed navigation reference hardware.
Focus on maintaining instrument fixation throughout the procedure.

Main Results:

The technique proved feasible and reliable for brain tumor biopsies.
Mean operative time was short at 18 minutes (SD 2.1).
The method ensured precision through a stable, fixed navigation reference.

Conclusions:

The described simple frameless technique is effective for navigation-guided brain biopsy.
Maintaining a stable navigation reference hardware enhances precision and reduces operative time.
This approach refines accuracy in frameless biopsy procedures.