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Updated: Nov 21, 2025
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
Published on: April 24, 2020
Prostate-specific membrane antigen positron emission tomography/computed tomography as a potential tool to assess and
Matthijs H Valstar1,2, Emilia C Owers3, Abrahim Al-Mamgani4
1Department of Head and Neck Oncology and Surgery, Antoni van Leeuwenhoek The Netherlands Cancer Institute, Amsterdam, the Netherlands.
Abstract:
Evaluation of salivary gland damage after head and neck radiotherapy (RT) is difficult with current tools, such as subjective patient-reported outcome measures. We demonstrate the use of prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET/CT) as an objective non-invasive tool to visualize damage to salivary glands resulting from RT. In three clinical cases, the PSMA-ligand distribution correlates to the RT dose distribution including intra-gland dose gradients and matches patient-reported toxicity, suggesting a dose-response relation. These findings support further exploration of PSMA PET/CT to guide and evaluate RT, with the ultimate aim to reduce salivary gland toxicity.
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