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Updated: Nov 21, 2025

Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
Published on: March 5, 2016
Catheter-related deep vein thrombosis in newborn infants
María C Rubio Longo1, Patricio M De Lucca2, Gustavo Goldsmit2
1Área de Neonatología, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina. crubio@garrahan.gov.ar.
Introduction:
In neonatology, more than 90 % of deep vein thromboses are related to catheter use. The objective of this study was to determine the incidence and risk factors associated with central venous catheter-related deep vein thrombosis.
Population And Methods:
Observational and analytical study conducted in a prospective cohort. All central venous catheters were included using consecutive, non-random sampling. The screening protocol included a daily clinical examination and a Doppler ultrasound (7-10 days after insertion and/or 72 h after removal). Follow-up: from catheter insertion to catheter removal, death or patient counter-referral. The incidence density rate per 1000 catheter-days was estimated with its corresponding 95 % confidence intervals (CIs), and risk factors, using Cox multivariate analysis.
Results:
Thrombosis was identified in 22/264 catheters. The incidence density rate of thrombosis was 5.33 ‰ catheter-days (95 % CI: 3.34-8.07). Cardiovascular surgery and and the use of central catheters others than peripherally inserted ones, were independent risk factors for thrombosis (hazard ratio: 3.8 [95 % CI: 1.6-9] and 2.75 [95 % CI: 1.17-6.45]).
Conclusions:
The incidence of central venous catheter-related deep vein thrombosis was 5.33 per 1000 catheter-days. A history of cardiovascular surgical procedures and and the use of central catheters others than peripherally inserted ones, were associated with a higher risk of this complication.
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