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Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
Urinary stone epidemiology in Spain and worldwide
Ana Morales-Martínez1, Mª Teresa Melgarejo-Segura1, Miguel A Arrabal-Polo2
1Hospital Universitario Clínico San Cecilio. Granada. España.
Urinary stones are increasingly common worldwide, affecting adults aged 40-60 most frequently. Calcium oxalate stones remain prevalent, while causes in children require further study.
Area of Science:
- Urology
- Nephrology
- Public Health
Background:
- Urinary stone disease incidence and prevalence are rising globally, with significant increases observed in the US and Spain.
- The 40-60 age group experiences the highest incidence, and recent trends show no sex-based differences, possibly linked to diet and obesity.
- While more common in Western countries, high prevalence is also noted in the Middle East, such as Saudi Arabia.
Purpose of the Study:
- To analyze the current global trends in urinary stone disease.
- To examine the composition and demographic variations of urinary stones.
- To highlight the differences in understanding pediatric versus adult urinary stone disease.
Main Methods:
- Review of epidemiological data on urinary stone prevalence and incidence.
- Analysis of lithiasis composition trends.
- Comparison of disease characteristics in adults and children.
Main Results:
- Global prevalence has increased significantly over the past decades.
- Calcium oxalate stones are the most common type (70-80%), with a rise in uric acid stones and a decline in infective stones.
- In children, stones are rare in early life, becoming more prevalent from adolescence, with calcium oxalate being the most common type (50-60%).
Conclusions:
- Urinary stone disease is a growing global health concern with shifting etiological factors.
- Calcium oxalate remains the predominant stone type, but uric acid stones are increasing.
- Etiopathogenic factors for urinary stones in children are less understood than in adults.
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