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Penoscrotal Paget's disease
J-N Dauendorffer1, F Herms1, B Baroudjian1
1Department of Dermatology, Hôpital Saint-Louis, Paris, France.
Annales De Dermatologie Et De Venereologie
|January 19, 2021
Summary
Paget's disease (PD) is an intra-epidermal adenocarcinoma. Penoscrotal extramammary Paget's disease (EMPD) is rare and less associated with other cancers than mammary PD, but prostate cancer is a common comorbidity.
Area of Science:
- Oncology
- Dermatology
- Pathology
Background:
- Paget's disease (PD) is an intra-epidermal adenocarcinoma.
- Extramammary Paget's disease (EMPD) can present in various locations, with penoscrotal forms being less common than vulvar or perianal.
- Penoscrotal EMPD is less frequently associated with secondary malignancies compared to mammary PD.
Purpose of the Study:
- To describe the characteristics of penoscrotal extramammary Paget's disease.
- To review associated neoplasms and treatment options for penoscrotal EMPD.
Main Methods:
- Histopathological examination for diagnosis.
- Clinical review of associated neoplasia.
- Surgical and non-surgical treatment modalities.
Main Results:
- Penoscrotal EMPD requires histopathological confirmation.
- Associated cancers, though less frequent than in MPD, often involve neighboring organs like the prostate or cutaneous adnexal tumors.
- Surgical excision is the primary treatment.
Conclusions:
- Penoscrotal EMPD is a rare presentation of Paget's disease.
- While less associated with systemic cancers, vigilance for prostate and adnexal tumors is warranted.
- Surgical excision is the mainstay of treatment, with alternative therapies available.
