Morning glory disc anomaly-associated maculopathy: multimodal imaging.

Area of Science:

• Ophthalmology
• Retinal Imaging
• Pathophysiology

Background:

• Morning glory disc anomaly (MGDA) is a rare congenital condition affecting the optic nerve head.
• MGDA is associated with vision impairment and an increased risk of developing maculopathy or retinal detachment later in life.
• The underlying mechanisms of MGDA-associated maculopathy remain poorly understood.

Observation:

• A case of a 31-year-old Black woman presenting with progressive vision reduction in the right eye due to MGDA-associated maculopathy.
• Detailed morphological analysis of the optic disc and macula was performed using multicolour imaging and optical coherence tomography.
• The patient's presentation highlights MGDA-associated maculopathy in an underrepresented demographic and age group.

Findings:

• The study identified specific morphological characteristics of the optic disc and macula in the observed case.
• Speculation on the role of centripetal inner retina traction in fluid accumulation within the inner retina.
• Hypothesis regarding the influence of cerebrospinal fluid pressure fluctuations on the development of retinoschisis in MGDA.

Implications:

• The findings suggest novel potential mechanisms contributing to retinoschisis in Morning glory disc anomaly.
• Highlights the need for further research into the cause-and-effect relationship between MGDA and retinoschisis.
• Contributes to a broader understanding of MGDA-associated maculopathy beyond typical demographics.