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Updated: Nov 21, 2025

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
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Skin barrier dysfunction and filaggrin.

Yeonjoon Kim1, Kyung-Min Lim2

  • 1Qmine Co., Ltd, 122B, 150 Bukahyun-ro, Seodaemun-gu, Seoul, 03760, Korea. yeonjoonkim@gmail.com.

Archives of Pharmacal Research
|January 19, 2021
PubMed
Summary
This summary is machine-generated.

Filaggrin protein is crucial for skin barrier function and hydration. Its deficiency causes skin disorders, but new therapies targeting filaggrin show promise for treating these conditions.

Keywords:
Atopic dermatitisFilaggrinSkin barrierSkin disorders

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Area of Science:

  • Dermatology
  • Biochemistry
  • Molecular Biology

Background:

  • Skin barrier dysfunction underlies conditions like atopic dermatitis and xerosis.
  • Filaggrin protein is essential for skin structure and natural moisturizing factors.
  • Filaggrin aggregation and degradation are key to stratum corneum integrity.

Purpose of the Study:

  • To review the roles and biology of filaggrin in skin barrier function.
  • To discuss skin diseases associated with filaggrin deficiency or dysfunction.
  • To explore therapeutic strategies targeting filaggrin for skin disorders.

Main Methods:

  • Literature review of filaggrin's biological roles.
  • Analysis of filaggrin's involvement in skin pathophysiology.
  • Discussion of current and emerging drug candidates targeting filaggrin.

Main Results:

  • Filaggrin aggregation forms a keratin network crucial for skin strength.
  • Filaggrin degradation yields natural moisturizing factors like trans-urocanic acid.
  • Deficiency or dysfunction of filaggrin is linked to various skin barrier disorders.

Conclusions:

  • Filaggrin is central to skin barrier integrity and hydration.
  • Therapeutic strategies targeting filaggrin offer potential for treating skin barrier disorders.
  • Several drug candidates targeting filaggrin are under clinical investigation.