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Synthesis, Characterization, and 3D Printing of an Isosorbide-Based, Light-Curable, Degradable Polymer for Potential
Nazanin Owji1, Alaa Aldaadaa, Jae-Ryung Cha2
1RAFT, Regenerative Biomaterials Group, The RAFT Institute, Mount Vernon Hospital, Northwood HA6 2RN, U.K.
ACS Biomaterials Science & Engineering
|January 19, 2021
Summary
Researchers developed novel methacrylate-based polymers for bone tissue engineering. These light-curable materials show promise for complex craniofacial defect reconstruction and 3D printing applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Polymer Chemistry
Background:
- Maxillofacial reconstruction faces challenges with large defects.
- Light-curable methacrylate-based polymers offer potential for bone repair.
- 3D printing enables complex structure fabrication for functional and aesthetic restoration.
Purpose of the Study:
- To synthesize mechanically stable and biologically functional polymers for craniofacial defect reconstruction.
- To evaluate the properties and printability of novel methacrylate-based polymers.
- To assess the biocompatibility of the synthesized materials for bone tissue engineering.
Main Methods:
- Synthesis of two novel methacrylate-based monomers, CSMA-1 and CSMA-2.
- Fabrication of composite samples and characterization using nuclear magnetic resonance (NMR) and biaxial flexural testing.
- In vitro cell culture with human bone marrow-derived mesenchymal stem cells (hMSCs) to assess cytotoxicity.
- 3D printing via direct photopolymerization to create constructs.
Main Results:
- NMR confirmed successful synthesis of CSMA-1 and CSMA-2 monomers.
- Modulus of elasticity for CSMA-1, CSMA-2, and their composites ranged from 1 to 3 GPa.
- In vitro studies demonstrated no cytotoxicity of the materials to hMSCs.
- Successful 3D printing of the bio-ink into complex constructs was achieved.
Conclusions:
- The synthesized methacrylate-based polymers (CSMA-1 and CSMA-2) are mechanically stable and biocompatible.
- These materials are suitable for 3D printing, offering a viable solution for complex craniofacial defect reconstruction.
- The study highlights the potential of these novel polymers in advancing bone tissue engineering applications.
