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Green Approaches for Cancers Management: An Effective Tool for Health Care
Jitendra Gupta1, Ashima Ahuja1, Reena Gupta1
1Institute of Pharmaceutical Research, GLA University, Mathura-281406, Uttar Pradesh, India.
Background:
Cancer is one of the leading causes of an increasing number of deaths in modern society. As the population increases, there is an increased thrust for screening newer anticancer (phytoconstituents) agents to manage cancers. Around 35000 herbal phytoconstituents are obtained from plants, animals and marine sources to create awareness of green therapy in managing, reducing, and minimizing side effects of modern chemotherapeutics and radiation therapy. The herbal plants are the richest sources of natural remedies and bioactive compounds that promote medicines' alternative systems as a green approach for managing various cancers. The terpenoids, saponins, volatile oils, and flavonoid phytoconstituents are most efficiently used to manage cancer with minimal side effects.
Objective:
The objectives of the present study are to investigate the efficacious, potent and safe use of herbal phytoconstituents extracts in the management of cancers and study their mechanism of action through alteration of transcription proteins, blocking G-2/M phase, distortion of tubulin structure, generation of reactive oxygen species, lipid peroxidation, cell cycle arrest, and anti-proliferation induced cell apoptosis for target specific cancer treatment. The information was collected from databases such as ScienceDirect, PubMed, Google Scholar, Academia, MedLine, and WoS.
Methods:
The literature was surveyed, and keywords like cancer therapeutics, metastasis, proliferation, cell apoptosis, cell lines, phytoconstituents for cancer management, and related disorders were screened.
Results:
The findings suggested that the crude extracts act as an antioxidant, free radical scavenger, or anti-aging agent exploited in the management of cancers along with treatment of other infectious diseases like ulcers, gout, liver diseases, respiratory tract infection, renal disorders, blood disorders, CVD, anti-inflammatory and several wound infections.
Conclusion:
The phytoactive moieties having herbal extracts help improve the compromised immunity status of affected patients and provide measures for scientific studies of newer anticancer agents in herbal industries.
Insights
Herbal phytoconstituents offer a green therapy approach for cancer management, acting as antioxidants and free radical scavengers. These natural compounds can minimize side effects and improve patient immunity for targeted cancer treatments.
Area of Science:
- Phytochemistry
- Oncology
- Pharmacology
Background:
- Cancer is a leading cause of death, driving the search for novel anticancer agents.
- Herbal phytoconstituents from diverse sources offer a green therapy approach to cancer management.
- Terpenoids, saponins, volatile oils, and flavonoids are key phytoconstituents used in cancer treatment with minimal side effects.
Purpose of the Study:
- To investigate the efficacy, potency, and safety of herbal phytoconstituent extracts in cancer management.
- To elucidate the mechanisms of action, including effects on transcription proteins, cell cycle arrest, and apoptosis.
- To explore phytoconstituents as an alternative to conventional chemotherapeutics and radiation therapy.
Main Methods:
- Literature survey using databases like PubMed, Google Scholar, and Web of Science.
- Screening of keywords related to cancer therapeutics, metastasis, proliferation, and phytoconstituents.
- Analysis of information on mechanisms of action including cell cycle arrest and apoptosis induction.
Main Results:
- Crude herbal extracts exhibit antioxidant and free radical scavenging properties.
- These extracts are effective in managing cancers and other conditions like infections and inflammatory diseases.
- Phytoactive compounds enhance immune status in cancer patients.
Conclusions:
- Herbal phytoconstituents provide a promising avenue for developing newer anticancer agents.
- Green therapy using phytoconstituents can complement or serve as an alternative to conventional cancer treatments.
- Further scientific studies are warranted to harness the potential of herbal extracts in the pharmaceutical industry.
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