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Arbutin as a Therapeutic Agent: Protein Modulating Potential and Pharmacology Perspective
Sonia Singh1, Suman Sinha1, Ashima Ahuja1
1Institute of Pharmaceutical Research GLA University, 17km Stone, NH-2, Mathura-Delhi Road, Mathura, Chaumuhan, Uttar Pradesh-281406, India.
Current Topics in Medicinal Chemistry
|May 15, 2026
Summary
Arbutin, a natural compound, shows diverse pharmacological effects beyond skin lightening, including antioxidant and anti-inflammatory actions. Further research is needed to optimize its therapeutic use and clinical translation.
Area of Science:
- Pharmacology
- Natural Products Chemistry
Background:
- Arbutin, a glycosylated hydroquinone, is recognized for dermatological depigmenting effects.
- Emerging research highlights its broad pharmacological versatility, including antioxidant, anti-inflammatory, antimicrobial, anticancer, and neuroprotective properties.
Purpose of the Study:
- To review recent findings on arbutin's pharmacodynamics and mechanisms of action.
- To consolidate potential therapeutic applications and relevance in modern pharmacological research.
Main Methods:
- Literature review of recent studies on arbutin.
- Analysis of biochemical pathways, absorption, distribution, metabolism, and excretion (ADME).
- Evaluation of toxicity and clinical translation challenges.
Main Results:
- Arbutin exhibits a wide range of biological activities.
- Understanding of arbutin's biochemical pathways and ADME properties has advanced.
- Toxicity and clinical translation present challenges requiring further investigation.
Conclusions:
- Arbutin is a promising natural therapeutic agent with significant biomedical potential.
- Novel dosage forms and innovative strategies are necessary to enhance therapeutic outcomes.
- Further studies in molecular pharmacology, nanotechnology, and clinical evaluation are crucial for optimizing arbutin's potential.
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