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Overview of Immunotherapy in Lung Cancer: Present Landscape
Sonia Singh1, Pramod Kumar Singh2, Manas Kumar Jha3
1Institute of Pharmaceutical Research GLA University, 17km Stone, NH-2, Mathura-Delhi Road Mathura, Chaumuhan, Uttar Pradesh-281406, India.
Current Topics in Medicinal Chemistry
|July 6, 2026
Summary
Immunotherapy is revolutionizing lung cancer treatment, offering improved survival for non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Targeted immune checkpoint therapies are key to this progress.
Area of Science:
- Oncology
- Immunology
- Pulmonology
Background:
- Lung cancer is a leading cause of cancer mortality globally, with non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) as primary types.
- Traditional treatments like chemotherapy and radiation therapy for lung cancer are associated with significant adverse effects.
- Recent advancements highlight immunotherapy as a transformative approach, significantly improving survival rates in advanced lung cancer.
Purpose of the Study:
- To review current immunotherapeutic strategies for lung cancer.
- To focus on targeted therapies acting on immune checkpoints in NSCLC and SCLC.
- To explore the potential of immunotherapy as an adjuvant treatment.
Main Methods:
- Review of contemporary immunotherapeutic strategies.
- Examination of targeted therapies focusing on immune checkpoints.
- Analysis of clinical outcomes and potential applications.
Main Results:
- Immunotherapy has substantially improved overall survival in advanced NSCLC.
- Targeted immune checkpoint therapies are driving progress in managing both NSCLC and SCLC.
- These immunotherapeutic approaches are among the most effective current treatment options.
Conclusions:
- Immunotherapy represents a significant advancement in lung cancer management.
- Targeted immune checkpoint inhibitors offer promising therapeutic options for NSCLC and SCLC.
- Immunotherapy is expected to play an increasing role as an adjuvant treatment, potentially altering the lung cancer therapeutic landscape.
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