Monkeypox Virus: A Brief Overview of Epidemiology, Pathophysiology, and Emerging Treatment Strategies

Monkeypox (Mpox) is a pandemic disease and is recognised as a global threat in the European and American regions. Mpox has increased the global health burden on various health policymakers due to an increase in mortality rates. Furthermore, the widespread transmission of Mpox presents a challenge for health researchers and other scientists. The World Health Organization (WHO) considers Mpox a pandemic condition that affects nearly a million people across the globe. Mpox is regarded as a global health emergency worldwide that requires strategic implementation from different sectors like pharma, health care, and herbal industries for effective management.

The Mpox-related research and its impact on health were screened in the databases like PubMed, Scopus, Web of Science, Google Scholar, and ScienceDirect.

Advances in therapeutic approaches require the development of novel anti-M pox drugs and vaccines, which provide valuable insights for scientists and researchers in successful pharmaceutical intervention. It helps provide new research and clinical translation into animal studies for future therapeutic directions, reducing the health burden.

Mpox becomes a global threat and further requires pharmaceutical intervention due to the presence of multivariant virus mutant strains. Furthermore, the resistance to existing therapeutics requires screening for other alternative and targeted therapies for patients experiencing health impacts. This paper provides insights into the therapeutic intervention of Mpox, epidemiology, and pathogenesis of the virus. Further, it helps to improve patient compliance and reduce the global health burden. Additionally, it aims to provide better therapeutic approaches that can manage an Mpox infection.

Mpox has certain drawbacks of toxicity, drug resistance, dose dumping, and poor patient outcomes. It presents a challenge for researchers and health scientists. There is a constant surge to search for novel antiviral drugs that are capable of addressing drug resistance, toxicity, poor patient compliance, and other toxic side effects. It will further help to mitigate the global Mpox threat through in-depth analysis of complex pathological and physiological mechanisms.