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Global Therapeutic Approaches to Restrict SARS-CoV-2 Infection: A Review
Seema Rohilla1, Rahul Sharma2, Shivam Kumar Handa1
1Geeta Institute of Pharmacy, Geeta University, Naultha, Panipat, Haryana, 132145, India.
This review explores natural medicines, including Ayurvedic and Chinese traditions, for treating human coronavirus (SARS-CoV-2). Repurposing existing drugs and herbal remedies shows promise in preventing or slowing virus transmission.
Area of Science:
- Virology
- Pharmacology
- Public Health
Background:
- The novel coronavirus, SARS-CoV-2, caused a global health crisis in late 2019.
- Over 7.6 million cases and 0.42 million deaths were reported globally by June 2020.
- Effective treatments and vaccines are under development, with limited public data on safety and efficacy.
Purpose of the Study:
- To review the etiology of human coronavirus.
- To summarize the inhibitory effects of various medicinal systems against human coronavirus.
- To explore the potential of natural products and repurposed drugs as preventive measures.
Main Methods:
- Literature review of allopathic, Ayurvedic, homeopathic, and Chinese medicines.
- Analysis of existing drugs and herbal remedies for antiviral properties.
- Focus on oral formulations for ease of manufacturing and stability.
Main Results:
- Natural medicinal products are traditionally used for respiratory infections.
- Several drugs and herbal remedies demonstrated inhibitory effects against human coronavirus.
- Oral formulations offer advantages in stability and scale-up for prophylactic use.
Conclusions:
- Repurposing accessible drugs and herbal remedies can be effective in preventing or slowing SARS-CoV-2 transmission.
- Natural medicines offer a viable avenue for developing prophylactic strategies.
- Further research into the safety and efficacy of these interventions is warranted.
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