Injectable Porous Bioresorbable Composite Containing Fluvastatin for Bone Augmentation.

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Drug Delivery Systems

Background:

• Bone augmentation is crucial for treating bone defects.
• Current methods can be invasive.
• Developing injectable, bioactive materials is a key research area.

Purpose of the Study:

• To evaluate an injectable composite of calcium sulfate (CAS), fluvastatin (FS), and atelocollagen for bone augmentation in rats.
• To assess the composite's physical properties and in vivo bone regeneration capacity.

Main Methods:

• Composites were characterized for porosity and compressive strength.
• In vitro fluvastatin release kinetics were measured.
• The materials were injected into rat extraction sockets and cranial defects.
• Microcomputed tomography and histological analyses were performed at 2, 4, and 8 weeks.

Main Results:

• Composites exhibited high porosity (>55%) and sustained FS release (>30 days).
• FS-containing composites significantly increased new bone formation, bone mass, and bone density in maxillae and crania.
• The composite showed resorption and integration with cranial tissues.

Conclusions:

• The injectable CAS-FS-atelocollagen composite is a promising biomaterial for bone augmentation.
• It offers percutaneous application, bone replacement, and anabolic effects.
• The material functions as an effective drug delivery system for bone formation.