Customizable Composite Fibers for Engineering Skeletal Muscle Models.
Afsoon Fallahi1,2, Iman K Yazdi1,2, Ludovic Serex1
1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, United States.
ACS Biomaterials Science & Engineering
|January 19, 2021
Summary
Researchers developed new composite fibers for tissue engineering. These fibers, made with biocompatible cores and hydrogel sheaths, support cell growth and muscle tissue development, offering a promising scaffold for regenerative medicine.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Engineering functional tissue scaffolds mimicking native tissue properties remains a significant challenge.
- Existing methods often struggle to independently control cellular and tissue-level characteristics.
Purpose of the Study:
- To develop multicompartment composite fibers for advanced tissue engineering applications.
- To enable tailored control over mechanical, electrical, and cellular properties of engineered tissues.
Main Methods:
- Fabrication of composite fibers with biocompatible cores and hydrogel sheaths.
- Assembly of fibers using textile processes to create 3D constructs.
- Evaluation of fiber biocompatibility, mechanical robustness, and cellular support in vitro.
Main Results:
- The engineered composite fibers demonstrated mechanical robustness suitable for textile assembly.
- Fibers effectively supported adhesion, proliferation, and maturation of skeletal muscle cells.
- Modifications to fiber coatings showed potential for enhancing myogenesis in vitro.
Conclusions:
- Multicompartment composite fibers offer a versatile platform for tissue engineering.
- Textile assembly allows independent tuning of tissue-level properties.
- These fibers hold promise for skeletal muscle regeneration and other regenerative medicine applications.
Keywords:
biotextilesinterpenetrating network hydrogelsorgan weavingreinforced fibersskeletal musclestissue engineeringMore Related Videos
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