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Related Concept Videos

Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

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Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
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Types of Skeletal Muscle Fibers01:32

Types of Skeletal Muscle Fibers

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Skeletal muscles comprise various fibers, each with distinct characteristics and roles in movement and stability. They are mainly categorized into three types — fast-twitch, slow-twitch, and intermediate.
Fast-twitch fibers
Fast-twitch fibers, or Type II fibers, are designed for quick, powerful bursts of speed and strength. They reach peak tension within approximately 0.01 seconds following stimulation. Characterized by a large diameter and densely packed myofibrils, these fibers contain...
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Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

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Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
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Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

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De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription...
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Overview of Muscle Tissues01:25

Overview of Muscle Tissues

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The human body has three types of muscle tissue: skeletal, smooth, and cardiac. Each class has unique properties that enable them to perform specific functions. However, all muscle tissues share certain properties, including elasticity, contractility, and excitability. 
Elasticity
Elasticity is the ability of muscles to stretch and return to their original shape. This property is partly due to elastic fibers — macromolecules that run through the muscles. These fibers are firm and...
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Fascicle Arrangement in Skeletal Muscles01:25

Fascicle Arrangement in Skeletal Muscles

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Fascicles are bundles of muscle fibers in a skeletal muscle. Muscle fascicle arrangement is directly associated with the power and range of motion of various muscles. The configuration of these fascicles can vary, leading to different functional outcomes.
The four primary types of muscle based on fascicle arrangement are:
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Related Experiment Video

Updated: Nov 20, 2025

Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization
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Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization

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Customizable Composite Fibers for Engineering Skeletal Muscle Models.

Afsoon Fallahi1,2, Iman K Yazdi1,2, Ludovic Serex1

  • 1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, United States.

ACS Biomaterials Science & Engineering
|January 19, 2021
PubMed
Summary

Researchers developed new composite fibers for tissue engineering. These fibers, made with biocompatible cores and hydrogel sheaths, support cell growth and muscle tissue development, offering a promising scaffold for regenerative medicine.

Keywords:
biotextilesinterpenetrating network hydrogelsorgan weavingreinforced fibersskeletal musclestissue engineering

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Assessing Functional Metrics of Skeletal Muscle Health in Human Skeletal Muscle Microtissues
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High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System
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High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

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Engineering Fibrin-based Tissue Constructs from Myofibroblasts and Application of Constraints and Strain to Induce Cell and Collagen Reorganization
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High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System
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High-Throughput Contractile Measurements of Hydrogel-Embedded Intact Mouse Muscle Fibers Using an Optics-Based System

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Engineering functional tissue scaffolds mimicking native tissue properties remains a significant challenge.
  • Existing methods often struggle to independently control cellular and tissue-level characteristics.

Purpose of the Study:

  • To develop multicompartment composite fibers for advanced tissue engineering applications.
  • To enable tailored control over mechanical, electrical, and cellular properties of engineered tissues.

Main Methods:

  • Fabrication of composite fibers with biocompatible cores and hydrogel sheaths.
  • Assembly of fibers using textile processes to create 3D constructs.
  • Evaluation of fiber biocompatibility, mechanical robustness, and cellular support in vitro.

Main Results:

  • The engineered composite fibers demonstrated mechanical robustness suitable for textile assembly.
  • Fibers effectively supported adhesion, proliferation, and maturation of skeletal muscle cells.
  • Modifications to fiber coatings showed potential for enhancing myogenesis in vitro.

Conclusions:

  • Multicompartment composite fibers offer a versatile platform for tissue engineering.
  • Textile assembly allows independent tuning of tissue-level properties.
  • These fibers hold promise for skeletal muscle regeneration and other regenerative medicine applications.