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Updated: Nov 20, 2025

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides

Published on: September 7, 2019

Decrease lysyl oxidase activity in hearts of copper-deficient bovines.

Gabriela Cintia Postma¹, Carolina Natalia Nicastro¹, Laura Beatriz Valdez²

¹Universidad de Buenos Aires, Facultad de Ciencias Veterinarias, Cátedra de Patología, Av. San Martín 5285, C1427CWO, Ciudad Autónoma de Buenos Aires, Argentina.

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)

|January 19, 2021

Summary

Copper deficiency in cattle significantly reduces heart lysyl oxidase (LOX) enzyme activity, impacting collagen and elastin cross-linking. This finding helps explain cardiac lesions in deficient animals.

Keywords:

Cattle Copper deficiency Heart Lysyl oxidase

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Area of Science:

Veterinary Medicine
Biochemistry
Animal Nutrition

Background:

Lysyl oxidase (LOX) is a copper-dependent enzyme crucial for collagen and elastin cross-linking.
Dietary imbalances, such as high molybdenum and sulfur, can induce copper deficiency in cattle.

Purpose of the Study:

To quantify lysyl oxidase (LOX) enzyme activity in the hearts of bovines with experimentally induced copper deficiency.
To investigate the relationship between dietary copper levels and cardiac LOX activity in cattle.

Main Methods:

Myocardial tissue samples were collected from copper-deficient and control Holstein bovines.
Enzymatic activity of LOX was measured using a commercial kit following manufacturer's instructions.

Main Results:

Lysyl oxidase (LOX) activity was found to be 29% lower in the hearts of copper-deficient bovines compared to controls.
This reduction in LOX activity was statistically significant (p=0.03).

Conclusions:

This study provides the first report of LOX enzymatic activity in the hearts of copper-deficient bovines.
Diminished LOX activity may explain previously observed microscopic cardiac alterations in these animals.
Findings support the link between dietary copper intake and LOX activity, aiding understanding of bovine cardiac pathology.