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In Vivo Hard and Soft Tissue Response of Two-Dimensional Nanoparticle Incorporated Biodegradable Polymeric Scaffolds
Jason T Rashkow1, Yahfi Talukdar1, Gaurav Lalwani1
1Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York 11794-5281, United States.
ACS Biomaterials Science & Engineering
|January 20, 2021
Summary
Poly(lactic-co-glycolic acid) (PLGA) nanocomposite scaffolds with graphene oxide or molybdenum disulfide show promise for bone regeneration. These materials exhibit good biocompatibility and may enhance bone growth in tissue engineering applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Current bone tissue engineering scaffolds aim to improve properties using nanoparticles.
- Biodegradable polymers like PLGA are commonly used but can be enhanced.
Purpose of the Study:
- To investigate the in vivo biocompatibility of PLGA nanocomposite scaffolds.
- To assess the effect of graphene oxide nanoplatelets (GONPs) and molybdenum disulfide nanoplatelets (MSNPs) on bone regeneration.
Main Methods:
- PLGA nanocomposite scaffolds with GONPs or MSNPs were created.
- Scaffolds were implanted in rat tibia defects and subcutaneously for 2 or 6 weeks.
- Hard and soft tissue biocompatibility and bone growth were evaluated.
Main Results:
- Nanoparticle-reinforced scaffolds showed biocompatibility comparable to PLGA controls.
- Experimental groups exhibited enhanced bone growth compared to PLGA and empty defects.
- GONP and MSNP incorporation may assist in bone regeneration.
Conclusions:
- PLGA nanocomposite scaffolds with GONPs or MSNPs are biocompatible.
- These novel scaffolds demonstrate potential for improving bone regeneration in tissue engineering.
