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Multifunctional Rare-Earth Element Nanocrystals for Cell Labeling and Multimodal Imaging.

Bianca Grunert1, Jessica Saatz2, Katrin Hoffmann2

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|January 20, 2021
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Summary
This summary is machine-generated.

We developed multifunctional europium-doped gadolinium orthovanadate nanocrystals for multimodal cellular imaging. These probes offer red photoluminescence, MRI contrast enhancement, and elemental microscopy capabilities for cell labeling.

Keywords:
LA-ICP-MSMRIcell labeling probemultimodal imagingrare-earth element nanocrystals

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Imaging

Background:

  • Multimodal imaging requires probes with diverse functionalities.
  • Existing probes may lack sufficient optical, magnetic, and elemental detection capabilities.
  • Developing novel nanomaterials for integrated bioimaging is crucial.

Purpose of the Study:

  • To synthesize and characterize europium-doped gadolinium orthovanadate nanocrystals (Eu:GdVO4-PAA) for multimodal cellular imaging.
  • To evaluate their potential as optical probes, MRI contrast agents, and for elemental microscopy.
  • To demonstrate their efficacy in intracellular labeling of human stem cells and A549 cells.

Main Methods:

  • Solvothermal synthesis of Eu:GdVO4-PAA nanocrystals.
  • Characterization using X-ray diffraction (XRD), photoluminescence spectroscopy (PL), and transmission electron microscopy (TEM).
  • Assessment of MRI contrast agent properties (r1 relaxivity) and suitability for Laser Ablation-ICP-MS.

Main Results:

  • Polycrystalline nanocrystals with hydrodynamic diameter of 55 nm and crystal size of 36.7 nm were synthesized.
  • Eu:GdVO4-PAA exhibited red photoluminescence and functioned as a positive MRI contrast agent (r1 = 1.97 mM-1 s-1).
  • Nanocrystals were successfully used for intracellular labeling of human adipose-derived stem cells and A549 cells.

Conclusions:

  • Eu:GdVO4-PAA nanocrystals are versatile multifunctional probes for multimodal cellular imaging.
  • Their combination of optical, magnetic, and elemental detection properties makes them suitable for advanced bioimaging applications.
  • These nanocrystals show promise for applications in stem cell tracking and cancer cell imaging.