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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

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Lab-on-Microsphere-FRET-Based Multiplex Sensor Platform.

Vera Kuznetsova¹, Viktoria Osipova¹, Anton Tkach¹

¹Center of Information Optical Technology, ITMO University, 197101 Saint Petersburg, Russia.

Nanomaterials (Basel, Switzerland)

|January 20, 2021

Summary

This summary is machine-generated.

This study introduces a novel multiplex assay using polymer microspheres with quantum dots for sensitive biomarker detection. The system utilizes Förster resonance energy transfer for enhanced multiplex analysis of biological samples.

Keywords:

AgInS2 FRET cyanine dyes microspheres sensing ternary quantum dots time-resolved fluorescence spectroscopy

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Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Published on: September 7, 2018

Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Development of advanced sensor systems for multiplex analysis is crucial for detecting biomarkers.
Quantum dots (QDs) and polymer microspheres (PMS) offer unique optical properties for assay development.

Purpose of the Study:

To develop and investigate a novel multiplex assay model based on polymer microspheres encoded with AIS/ZnS quantum dots.
To explore Förster resonance energy transfer (FRET) for multiplexing capabilities in the designed system.

Main Methods:

Layer-by-layer deposition technique for preparing QD-encoded PMS.
Förster resonance energy transfer (FRET) studies between QDs and cyanine dyes.
Time-resolved photoluminescence (PL) measurements to analyze energy transfer dynamics.

Main Results:

QD photoluminescence quenching increased with decreased QD-dye distance.
Sensitized dye PL intensity showed a maximum at two double polyelectrolyte layers.
FRET led to decreased QD PL lifetime and increased dye PL lifetime, enabling multiplexing.

Conclusions:

The designed PMS encoded with AIS/ZnS QDs enable multiplexing by wavelength and PL lifetimes.
This system holds great potential for developing highly selective and sensitive sensor systems.
The assay can be used for multiplex analysis to detect biomarkers in cell lysates and body fluids.