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Updated: Nov 20, 2025

The Identification of Sea Lamprey Pheromones Using Bioassay-Guided Fractionation
Published on: July 17, 2018
New Haloterpenes from the Marine Red Alga Laurencia papillosa: Structure Elucidation and Biological Activity
Mohamed Shaaban1,2, Ghada S E Abou-El-Wafa3, Christopher Golz2
1National Research Centre, Chemistry of Natural Compounds Department, Division of Pharmaceutical Industries, El-Behoos St. 33, Dokki, Cairo 12622, Egypt.
Abstract:
Analysis of the air-dried marine red alga Laurencia papillosa, collected near Ras-Bakr at the Suez gulf (Red Sea) in Egypt delivered five new halogenated terpene derivatives: aplysiolic acid (1), 7-acetyl-aplysiol (2), aplysiol-7-one (3), 11,14-dihydroaplysia-5,11,14,15-tetrol (5a), and a new maneonene derivative 6, named 5-epi-maneolactone. The chemical structures of these metabolites were characterized employing spectroscopic methods, and the relative and absolute configurations were determined by comparison of experimental and ab initio-calculated NMR, NOE, ECD, and ORD data, and by X-ray diffraction of 2 and 6. The antimicrobial activities of the crude extract and compounds 1-3, 5a and 6 were studied.
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