Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A system approach to pharmacodynamics. I: Theoretical framework.

P Veng-Pedersen1, W R Gillespie

  • 1College of Pharmacy, University of Iowa, Iowa City 52242.

Journal of Pharmaceutical Sciences
|January 1, 1988
PubMed
Summary

This study introduces a general theoretical framework to mathematically describe the relationship between pharmacokinetic responses and pharmacologic effects. It explores mathematical structures for pharmacodynamic systems, aiding drug development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time-to-Event Analysis of Polatuzumab Vedotin-Induced Peripheral Neuropathy to Assist in the Comparison of Clinical Dosing Regimens.

CPT: pharmacometrics & systems pharmacology·2017
Same author

A Bayesian population analysis of the development of type 2 diabetes in the offspring of diabetic parents.

Journal of pharmacokinetics and pharmacodynamics·2011
Same author

The effect of anticoagulant, storage temperature and dilution on cord blood hematology parameters over time.

International journal of laboratory hematology·2008
Same author

Change in erythropoietin pharmacokinetics following hematopoietic transplantation.

Clinical pharmacology and therapeutics·2007
Same author

Individualized pharmacokinetic risk assessment for development of diabetes in high risk population.

Diabetes research and clinical practice·2007
Same author

Urinary excretion of darbepoetin after intravenous vs subcutaneous administration to preterm neonates.

Journal of perinatology : official journal of the California Perinatal Association·2006

Area of Science:

  • Pharmacokinetics and Pharmacodynamics
  • Mathematical Modeling in Pharmacology
  • Systems Biology

Background:

  • Understanding the relationship between drug concentration and effect is crucial for drug development.
  • Existing models often lack a unified theoretical framework to integrate pharmacokinetic and pharmacodynamic components.
  • Pharmacokinetic (PK) response (r) and pharmacologic effect (E) are linked but require a generalized mathematical description.

Purpose of the Study:

  • To construct a general theoretical framework for the PK/PD relationship.
  • To mathematically describe the link between pharmacokinetic response (r) and pharmacologic effect (E).
  • To explore specific mathematical structures applicable to pharmacodynamic systems.

Main Methods:

  • Developed a general operator-based mathematical framework: E = omega(r) = omega p(omega b(omega r(r))).

Related Experiment Videos

  • Analyzed the kinetic basis for applying mathematical properties like linearity.
  • Introduced specific mathematical structures for pharmacodynamic modeling, such as E = phi t(r) and E = phi p(psi p*phi b(psi r*r)).

    • Main Results:

    • A unified theoretical framework was established for PK/PD relationships.
    • The framework allows for the decomposition of the overall relationship into system components (e.g., PK, distribution, effect).
    • Several specific mathematical models were derived, applicable to diverse pharmacodynamic systems.

    Conclusions:

    • The proposed theoretical framework provides a robust mathematical foundation for PK/PD analysis.
    • This generalized approach facilitates a deeper understanding of drug action mechanisms.
    • The introduced mathematical structures can enhance the prediction and optimization of drug therapies.