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Abdominal symptoms during Sjogren's syndrome: a pilot study
Simon Parreau1,2, Jérémie Jacques3,4, Stéphanie Dumonteil5
1Internal Medicine Department, Limoges University Hospital, 16 rue du Professeur Bernard Descottes, 87042, Limoges, France. simon.parreau@hotmail.com.
Most primary Sjögren syndrome (pSS) patients experience abdominal symptoms like pain and constipation. Further research is needed to understand the causes and develop treatments for these common gastrointestinal issues in pSS.
Area of Science:
- Gastroenterology
- Rheumatology
- Clinical Medicine
Background:
- Abdominal symptoms are under-documented in primary Sjögren syndrome (pSS).
- Understanding these symptoms is crucial for patient care.
Purpose of the Study:
- To describe the prevalence and characteristics of abdominal symptoms in pSS patients.
- To investigate the association between abdominal symptoms and pSS disease characteristics.
Main Methods:
- 150 pSS patients were evaluated using a composite global symptom score for abdominal symptoms.
- Clinical and biological data of pSS and abdominal disorders were collected.
- Statistical analyses, including multivariate analysis, were performed.
Main Results:
- 95% of pSS patients reported abdominal symptoms, with common issues including abdominal tension, upper abdominal pain, discomfort, and constipation.
- High symptom scores correlated with general and central nervous system involvement, and ESSPRI scores.
- Significant associations were found between high symptom scores and SSA seronegativity, gastroparesis, and ESSPRI score.
Conclusions:
- The majority of primary Sjögren syndrome patients suffer from abdominal symptoms.
- Current lack of understanding of pathophysiological mechanisms limits therapeutic recommendations.
- Further research is needed to guide treatment strategies.
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