Related Experiment Video

Updated: Nov 20, 2025

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
10:33

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

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Roles and Regulations of TET Enzymes in Solid Tumors

Julie K Bray1, Meelad M Dawlaty2, Amit Verma2

  • 1Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Trends in Cancer
|January 20, 2021
PubMed

Insights

Ten-eleven translocation (TET) enzymes regulate DNA methylation dynamics. Deregulation of TET enzymes contributes to cancer development, highlighting their crucial role in carcinogenesis.

Area of Science:

  • Epigenetics
  • Cancer Biology
  • Molecular Oncology

Background:

  • The DNA methylome is crucial for gene regulation, impacting tumor suppressors and oncogenes.
  • Oxidized forms of 5-methylcytosine (5mC) have expanded our understanding of methylome regulation.
  • Ten-eleven translocation (TET) enzymes catalyze 5mC oxidation, influencing DNA demethylation and methylation dynamics.

Purpose of the Study:

  • To review the regulatory mechanisms of TET enzymes.
  • To explore the multifaceted roles of TET enzymes in carcinogenesis.
  • To understand how TET deregulation contributes to a cancer phenotype.

Main Methods:

  • Literature review of TET enzyme function in cancer.
  • Analysis of TET enzyme regulation tiers.
  • Overview of TET deregulation in carcinogenesis.

Main Results:

  • TET enzymes play a dynamic role in the global and local methylation landscape.
  • TET deregulation is implicated in promoting cancer phenotypes.
  • Understanding TET roles is key to epigenetic insights in carcinogenesis.

Conclusions:

  • TET enzymes are critical epigenetic regulators with significant roles in cancer.
  • Further research into tissue-specific and context-dependent TET functions is needed.
  • Defining these roles will advance our understanding of epigenetic perturbations in cancer.
Keywords:
5-hydroxymethylcytosinecarcinogenesisepigeneticsten-eleven translocation

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