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A short ORF-encoded transcriptional regulator

Minseob Koh1,2, Insha Ahmad1, Yeonjin Ko1

  • 1Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.

Proceedings of the National Academy of Sciences of the United States of America
|January 20, 2021
PubMed
Summary

Researchers developed a new method to identify interactions of short open reading frame (ORF)-encoded peptides (SEPs). This approach led to the discovery of SEHBP, a novel microprotein functioning as a short ORF-encoded transcription factor.

Keywords:
expanded genetic codephoto-crosslinkingshort open reading frame-encoded peptidetranscriptional regulation

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