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Gorham Stout disease: a case report from Syria.

Asil Esper¹, Sami Alhoulaiby², Areege Emran³

¹Neurology Department, Tishreen University Hospital, Halap street, Latakia, Syria.

Oxford Medical Case Reports

|January 20, 2021

Summary

Gorham-Stout disease (GSD) is a rare bone disorder causing osteolysis and fractures. This case highlights GSD diagnosis in a 60-year-old female and discusses treatment with Bisphosphonate for symptom relief.

Keywords:

Gorham Stout disease angiomatosis lytic bone disease osteolysis vanishing bone disease

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Area of Science:

Orthopedics
Pathology
Rare Diseases

Background:

Gorham-Stout disease (GSD) is a rare skeletal disorder characterized by progressive osteolysis.
It presents with bone pain, pathological fractures, and can lead to significant morbidity.

Observation:

A 60-year-old female presented with pathological fractures of the pelvis and absence of the left femoral head.
Biopsy revealed disturbed bone formation, increased vascularity, necrosis, and osteolysis, consistent with GSD.

Findings:

The histopathological findings excluded other conditions, confirming the diagnosis of Gorham-Stout disease.
Treatment with bisphosphonate resulted in relative symptomatic improvement.

Implications:

This case underscores the importance of considering GSD in the differential diagnosis of unexplained osteolysis and fractures.
Further research is needed to elucidate the etiology and optimal management strategies for Gorham-Stout disease.