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Related Concept Videos

Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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CEST MRI trackable nanoparticle drug delivery systems.

Zheng Han1, Guanshu Liu1,2

  • 1Russell H. Morgan Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

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|January 20, 2021
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Chemical exchange saturation transfer (CEST) MRI enables tracking of nanoparticle drug delivery systems (nano-DDSs). This advanced imaging method allows for real-time monitoring of drug distribution and nanoparticle behavior in vivo.

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Area of Science:

  • Nanomedicine
  • Biomedical Imaging
  • Drug Delivery Systems

Background:

  • Nanoparticle drug delivery systems (nano-DDSs) offer improved therapeutic efficiency and reduced side effects.
  • Image guidance is crucial for nanomedicine, aiding in tracking, monitoring, and optimizing treatment.
  • Conventional MRI methods have limitations in detecting certain compounds relevant to nanomedicine.

Purpose of the Study:

  • To review the development and application of CEST MRI-trackable nano-DDSs.
  • To highlight the advantages of CEST MRI in nanomedicine.
  • To discuss the potential of CEST MRI for image-guided drug delivery.

Main Methods:

  • Review of recently developed CEST MRI-trackable nano-DDSs.
  • Discussion of various nanoparticle types including liposomes, polymeric nanoparticles, drug-based nanoparticles, and carbon dots.
  • Analysis of CEST MRI's capability to detect diamagnetic compounds and nano-carriers.

Main Results:

  • CEST MRI is a powerful tool for non-invasive in vivo tracking of nanoparticles and their loaded drugs.
  • CEST MRI enables high-spatial-resolution detection of a broad spectrum of bioorganic agents and nano-carriers.
  • Various nano-DDS formulations are demonstrated to be trackable using CEST MRI.

Conclusions:

  • CEST MRI is a promising imaging modality for image-guided drug delivery.
  • The ability of CEST MRI to detect diverse compounds enhances its utility in nanomedicine.
  • Future perspectives in CEST MRI-guided nanomedicine are discussed.