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Doctor-Should I get the COVID-19 vaccine? Infection and immunization in individuals with neuromuscular disorders
Sasha A Živković1, Gregory Gruener2, Pushpa Narayanaswami3
1Department of Neurology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Abstract:
The clinical course of neuromuscular disorders (NMDs) can be affected by infections, both in immunocompetent individuals, and in those with reduced immunocompetence due to immunosuppressive/immunomodulating therapies. Infections and immunizations may also trigger NMDs. There is a potential for reduced efficacy of immunizations in patients with reduced immunocompetence. The recent vaccination program for coronavirus disease-2019 (COVID-19) raises several questions regarding the safety and efficacy of this vaccine in individuals with NMDs. In this Practice Topic article, we address the role of vaccine-preventable infections in NMDs and the safety and efficacy of immunization in individuals with NMDs, with emphasis on vaccination against COVID-19.
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