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Related Experiment Video

Updated: Nov 20, 2025

Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay

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Published on: May 12, 2020

The Correlation Between Metabolic Disorders And Tpoab/Tgab: A Cross-Sectional Population-Based Study.

Ying Wu¹, Xiaoguang Shi¹, Xulei Tang²

¹From the Department of Endocrinology and Metabolism and the institute of Endocrinology, The First Hospital of China Medical University, Shenyang, Liaoning, P.R. China; These authors contributed equally to this work.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

|January 20, 2021

Summary

Metabolic disorders like obesity and high LDL-C are linked to higher thyroid autoantibodies in euthyroid individuals. These associations differ between males and females, highlighting a gender-dependent relationship.

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Last Updated: Nov 20, 2025

Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay

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Published on: May 12, 2020

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

Area of Science:

Endocrinology and Immunology
Metabolic Syndrome Research
Thyroid Disease Etiology

Background:

Metabolic abnormalities significantly impact immune system function.
Increasing prevalence of metabolic and autoimmune thyroid diseases necessitates exploring their correlation.
Previous research indicates a link between metabolic dysfunction and immune responses.

Purpose of the Study:

To investigate the relationship between metabolic disorders and thyroid autoantibodies (TPOAbs and TgAbs) in euthyroid subjects.
To explore potential gender-specific associations between metabolic parameters and thyroid autoimmunity.
To identify specific metabolic derangements associated with positive thyroid autoantibodies.

Main Methods:

Cross-sectional survey of 55,891 subjects from China.
Evaluation of body mass index (BMI), waist circumference (WC), blood pressure, thyroid autoantibodies (TPOAbs, TgAbs), TSH, glucose, lipids, and uric acid.
Multivariate analysis to determine odds ratios for associations between metabolic factors and thyroid autoantibodies.

Main Results:

In males, higher BMI, WC, blood pressure, and glucose levels were observed in the TPOAb-/TgAb-positive group.
In females, elevated BMI, WC, blood pressure, total cholesterol, and LDL-C were found in the TPOAb-/TgAb-positive group.
Multivariate analysis revealed significant associations: abdominal obesity with TgAbs in males (OR 1.175), hyperuricemia with TPOAbs in males (OR 1.195), and high LDL-C with TgAbs in females (OR 1.19).

Conclusions:

Obesity, high LDL-C, and hyperuricemia are positively correlated with thyroid autoantibodies in euthyroid subjects.
The association between metabolic disorders and positive thyroid autoantibodies is gender-dependent.
Metabolic health status is an important factor to consider in the context of thyroid autoimmunity.