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Clinical Applications of Epidermal Stem Cells

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...

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Related Experiment Video

Updated: Nov 20, 2025

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Magnetic and Thermal-sensitive PolyN-isopropylacrylamide-based Microgels for Magnetically Triggered Controlled Release

Published on: July 4, 2017

Curcumin-Loaded Self-Microemulsifying Gel for Enhancing Wound Closure.

Jiun Wen Guo^1,2, Chi-Ming Pu^3,4, Chih-Yi Liu⁵

¹Department of Medical Research, Cathay General Hospital, Taipei, Taiwan.

Skin Pharmacology and Physiology

|January 20, 2021

Summary

Curcumin-loaded self-microemulsifying gel improved wound healing and skin permeation compared to commercial gels. This novel delivery system shows promise for advanced wound care and skin disease treatment.

Keywords:

Curcumin Self-microemulsifying gel Skin Topical gel Wound healing

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Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Area of Science:

Biomedical Engineering
Materials Science
Pharmacology

Background:

Wound healing involves complex cellular and protein interactions for tissue repair.
Bioactive drug-loaded dressings offer advanced wound healing with controlled delivery.
Curcumin shows potential for wound healing but faces solubility and absorption challenges.

Purpose of the Study:

To investigate the therapeutic efficacy of curcumin-loaded self-microemulsifying gel for wound healing.
To evaluate curcumin's enhanced delivery and therapeutic effects using a novel gel formulation.

Main Methods:

Ex vivo skin permeation studies using mouse skin and a diffusion cell system.
In vivo assessment of therapeutic effects on full-thickness wound models in mice.
Topical application of gels over 12 days to monitor wound closure.

Main Results:

Curcumin-loaded self-microemulsifying gel demonstrated superior skin flux, cumulative amount, and permeability coefficient compared to commercial gels.
The novel gel formulation significantly enhanced wound healing in the in vivo model.
Improved skin absorption and sustained release properties were observed.

Conclusions:

This study introduces curcumin-loaded self-microemulsifying gel as a pioneering delivery system for wound healing.
The enhanced permeation and wound healing effects warrant further investigation for skin disease treatment applications.
Further research is recommended to explore the full potential of this delivery system.