Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Brain Imaging01:14

Brain Imaging

480
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
480

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early α-synuclein-mediated mitochondrial dysfunction in a human cell model of Parkinson's disease dementia.

Communications biology·2026
Same author

ZFTA-RELA ependymomas make itaconate to epigenetically drive fusion expression.

Nature·2026
Same author

Childhood brain tumors instruct cranial hematopoiesis and immunotolerance.

Nature genetics·2026
Same author

Investigation of a global mouse methylome atlas reveals subtype-specific copy number alterations in pediatric cancer models.

Nature genetics·2025
Same author

The invasion phenotypes of glioblastoma depend on plastic and reprogrammable cell states.

Nature communications·2025
Same author

Retraction Note: Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis.

Nature·2025
Same journal

Retinoic acid and FGF signaling interact to control elongation and lineage specification in a mouse gastruloid model.

Development (Cambridge, England)·2026
Same journal

Expanding the C. elegans toolkit with gonad explants.

Development (Cambridge, England)·2026
Same journal

Nuclear Factor Y controls nutrient-adaptive epithelial growth by regulating mTOR in the Drosophila midgut.

Development (Cambridge, England)·2026
Same journal

Primordial germ cells differentially contribute to the germline in zebrafish.

Development (Cambridge, England)·2026
Same journal

Dissecting planar and vertical organiser signals in early chick neural development.

Development (Cambridge, England)·2026
Same journal

Real-time transcriptomic profiling of hPSC-derived cartilage during development identifies a key role for the extracellular matrix in homeostasis and protection.

Development (Cambridge, England)·2026
See all related articles

Related Experiment Video

Updated: Nov 20, 2025

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

590

Harnessing brain development to understand brain tumours.

Silvia Marino1, Richard J Gilbertson2,3

  • 1Blizard Institute, Barts Brain Tumour Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK s.marino@qmul.ac.uk.

Development (Cambridge, England)
|January 21, 2021
PubMed
Summary
This summary is machine-generated.

Pediatric brain tumors are the most common childhood solid cancers. Understanding developmental biology aids in comprehending tumor causes and improving treatment strategies for affected children.

Keywords:
Diffuse intrinsic pontine gliomaEpendymomaMedulloblastomaPaediatric tumours

More Related Videos

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

18.4K
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.1K

Related Experiment Videos

Last Updated: Nov 20, 2025

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device
07:44

Establishment of Orthotopic Patient-derived Xenograft Models for Brain Tumors using a Stereotaxic Device

Published on: May 2, 2025

590
Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting
08:14

Processing of Primary Brain Tumor Tissue for Stem Cell Assays and Flow Sorting

Published on: September 25, 2012

18.4K
Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping
13:12

Translational Brain Mapping at the University of Rochester Medical Center: Preserving the Mind Through Personalized Brain Mapping

Published on: August 12, 2019

46.1K

Area of Science:

  • Pediatric oncology
  • Developmental biology
  • Cancer pathogenesis

Background:

  • Brain tumors represent the most frequent solid neoplasms in children.
  • These neoplasms account for 25% of all childhood cancers.
  • Advances in developmental biology offer insights into tumor origins.

Purpose of the Study:

  • To explore the link between developmental mechanisms and pediatric brain tumor pathogenesis.
  • To discuss the impact of this knowledge on clinical treatment decisions.

Main Methods:

  • Review of current literature on pediatric brain tumor development.
  • Analysis of the role of developmental pathways in tumorigenesis.
  • Evaluation of how basic science discoveries inform clinical practice.

Main Results:

  • Knowledge of developmental biology is crucial for understanding pediatric brain tumor formation.
  • This understanding is beginning to influence treatment approaches for childhood brain tumors.

Conclusions:

  • Continued research into developmental mechanisms will enhance our understanding of pediatric brain tumors.
  • Translating developmental insights into clinical practice is key to improving patient outcomes.