Related Experiment Video
Updated: Nov 20, 2025

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
Published on: April 5, 2018
Insights into the Links between MYC and 3D Chromatin Structure and Epigenetics Regulation: Implications for Cancer
Fatemeh Amjadi-Moheb1, Alireza Paniri1, Haleh Akhavan-Niaki2
1Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Abstract:
MYC is embedded in the transcriptional oasis of the 8q24 gene desert. A plethora of genomic elements has roles in MYC aberrant expression in cancer development by interacting with transcription factors and epigenetics regulators as well as altering the structure of chromatin at the MYC locus and tissue-specific long-range enhancer-promoter contacts. Furthermore, MYC is a master regulator of several human cancers by modulating the transcription of numerous cancer-related genes through epigenetic mechanisms. This review provides a comprehensive overview of the three-dimensional genomic organization around MYC and the role of epigenetic machinery in transcription and function of MYC as well as discusses various epigenetic-targeted therapeutic strategies in MYC-driven cancers.
Related Concept Videos
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
Induced Pluripotent Stem Cells
Somatic...
Spreading of Chromatin Modifications
Writers
The writer...
Abnormal Proliferation
Histone Modification
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone...

