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Updated: Jul 8, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

6.8K

The epigenetics orchestra of Notch signaling: a symphony for cancer therapy

Alireza Paniri1,2, Mohammad Mahdi Hosseini3, Fatemeh Amjadi-Moheb1

  • 1Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, 4717647745,Iran.

Epigenomics
|December 19, 2023
PubMed

Insights

Aberrant Notch signaling is linked to cancer. Epigenetic modifications offer new therapeutic strategies for Notch pathway-targeted cancer treatments.

Area of Science:

  • Cellular signaling
  • Cancer biology
  • Epigenetics

Background:

  • The Notch signaling pathway is crucial for development and its dysregulation is implicated in various human cancers.
  • Notch pathway activity can promote or suppress tumors, depending on the cellular context.
  • Epigenetic modifications can influence Notch pathway signaling.

Purpose of the Study:

  • To review the regulatory mechanisms of Notch signaling.
  • To explore the therapeutic potential of targeting Notch signaling through epigenetic modifications.

Main Methods:

  • Literature review of Notch signaling pathways.
  • Analysis of epigenetic modifications affecting Notch ligands and receptors.
  • Discussion of therapeutic strategies targeting the Notch pathway.

Main Results:

  • The Notch pathway's dual role as an oncogene or tumor suppressor is context-dependent.
  • Epigenetic mechanisms provide a means to modulate Notch signaling.
  • Targeting epigenetic regulation offers potential for novel cancer therapies.

Conclusions:

  • Understanding Notch signaling regulation is key to developing effective cancer treatments.
  • Epigenetic-based therapeutics targeting the Notch pathway hold promise for single and combination treatments.
Keywords:
NOTCHcancerepigeneticsncRNAstherapy

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