Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoimmunity in multiple sclerosis.

J De Keyser1

  • 1Department of Neurology, National Hospital for Nervous Diseases, London, UK.

Neurology
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

Multiple sclerosis (MS) patients do not have a higher prevalence of autoimmune disorders. However, MS patients showed increased autoantibodies, suggesting a nonspecific B cell overactivity in this condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification and characterization of a new ensemble of cometary organic molecules.

Nature communications·2022
Same author

Perceived neuropsychological impairment inversely related to self-reported health and employment in multiple sclerosis.

European journal of neurology·2019
Same author

On the origin of molecular oxygen in cometary comae.

Nature communications·2018
Same author

European Academy of Neurology and European Stroke Organization consensus statement and practical guidance for pre-hospital management of stroke.

European journal of neurology·2017
Same author

Xenon isotopes in 67P/Churyumov-Gerasimenko show that comets contributed to Earth's atmosphere.

Science (New York, N.Y.)·2017
Same author

D<sub>2</sub>O and HDS in the coma of 67P/Churyumov-Gerasimenko.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2017
Same journal

Factors Associated With Disability Improvement and Worsening Independent of Attacks in Patients With AQP4-IgG+ NMOSD and MOGAD: A Multicenter Cohort Study.

Neurology·2026
Same journal

Cost-Effectiveness of Intracranial Aneurysm Screening: A Systematic Review.

Neurology·2026
Same journal

Rare Eating Epilepsy: Co-Occurrence of Focal Cortical Dysplasia and Gray Matter Heterotopia.

Neurology·2026
Same journal

Spatiotemporal Associations Between Cortical Microinfarcts and Cortical Superficial Siderosis in Cerebral Amyloid Angiopathy.

Neurology·2026
Same journal

Blood-Brain Barrier Disruption Before Interhospital Transfer for Thrombectomy and Clinical Outcome.

Neurology·2026
Same journal

At Death's Door: Cytosolic Dopamine in Patients With Parkinson Disease.

Neurology·2026
See all related articles

Area of Science:

  • Neurology
  • Immunology
  • Autoimmune Diseases

Background:

  • Multiple sclerosis (MS) is often associated with autoimmune disorders.
  • The actual prevalence of these coexisting conditions in MS patients requires further investigation.

Purpose of the Study:

  • To investigate the prevalence of autoimmune disorders in patients with multiple sclerosis (MS).
  • To determine if MS patients exhibit a higher frequency of autoantibodies compared to controls.

Main Methods:

  • Retrospective review of medical records for 828 patients with definite MS.
  • Analysis of autoimmune disorder prevalence in the MS cohort.
  • Serum autoantibody testing (antinuclear, thyroid, parietal cell, smooth muscle, mitochondrial) in 105 MS patients and 105 controls with other neurologic disorders.

Related Experiment Videos

Main Results:

  • 4.8% of MS patients had a history of autoimmune disorders, a prevalence similar to the general population.
  • MS patients without clinical autoimmune disorders showed a significantly higher prevalence of low-titer autoantibodies compared to controls (p < 0.01).

Conclusions:

  • The co-occurrence of diagnosed autoimmune disorders is not elevated in multiple sclerosis (MS) patients.
  • Elevated autoantibody levels in MS patients may indicate a general B cell hyperactivity, rather than specific autoimmune conditions.