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Targeting the integrated stress response in ophthalmology

Hsiao-Sang Chu1,2,3, Cornelia Peterson4, Albert Jun1

  • 1Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University, Baltimore, MD, USA.

Current Eye Research
|January 21, 2021
PubMed
Summary

The Integrated Stress Response (ISR) pathway is crucial for cellular survival in the eye, regulating protein translation under stress. Targeting the ISR offers potential treatments for various ophthalmic diseases.

Keywords:
ATF4ISR; isrib, cornea; eIF2

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