Related Experiment Video
Updated: Jul 16, 2026
08:51
Genome-wide RNAi Screening to Identify Host Factors That Modulate Oncolytic Virus Therapy
Published on: April 3, 2018
Pediatric Oncology Knowledge Mobilization in Canada: A Environmental Scan
Catherine Foulem1, Emily K Drake1,2,3, Angelina Lui4
1Gerald Bronfman Department of Oncology, Faculty of Medicine and Health Sciences, McGill University, Montréal, QC, Canada.
Summary
Canadian non-profit organizations support pediatric oncology knowledge sharing, but gaps exist in bilingual content and centralized resources. This study maps their dissemination efforts, identifying strengths and areas for improvement.
Area of Science:
- Pediatric Oncology
- Non-profit Organizations
- Knowledge Dissemination
Background:
- Non-profit organizations are crucial for knowledge dissemination in pediatric oncology.
- Their specific contributions, both online and in-person, require detailed examination.
- Understanding their efforts is key to strengthening support for pediatric cancer patients and families.
Purpose of the Study:
- To map the Canadian pediatric oncology non-profit landscape.
- To describe their knowledge mobilization and dissemination strategies.
- To identify strengths, gaps, and opportunities for collaboration.
Main Methods:
- Conducted a bilingual, internet-based environmental scan of Canadian pediatric oncology non-profits.
- Screened organizations and extracted data on characteristics and dissemination strategies.
- Analyzed data descriptively and presented findings using tables, spatial data, and figures.
Main Results:
- Identified 25 eligible organizations, with 44% located in Ontario.
- Most organizations were founded between 2000-2009 (36%) and offered English-only content (72%).
- All utilized websites and social media (Facebook, Instagram); only 26.1% provided bilingual resources.
Conclusions:
- The study provides a comprehensive overview of Canadian pediatric oncology non-profits and their dissemination activities.
- Significant gaps were identified in bilingual content, multilingual resources, geographic distribution, and centralized information hubs.
- Recommendations include addressing these gaps to enhance resource accessibility and collaborative efforts.
Related Concept Videos
01:24Pharmacokinetics in Pediatric Patients: Drug Metabolism
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
01:17Pharmacokinetics in Pediatric Patients: Drug Distribution
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
01:26Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
02:56Treatment Resistent Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
02:56Treatment Resistant Cancers
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...