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A Comprehensive Review on Pellets as a Dosage Form in Pharmaceuticals
Maithri S Handattu1, Shailesh Thirumaleshwar1, Gowrav M Prakash1
1Department of Pharmaceutics, Industrial Pharmacy, JSS College of Pharmacy, Sri Shivarathreeshwara Nagara, JSS Academy of Higher Education and Research, Sri Shivarathreeshwara Nagara, Mysuru-570015, Karnataka, India.
This review explores pellets, a type of multiparticulate system, highlighting their advantages for oral drug delivery and sustained release formulations. It covers pelletization techniques, characterization, and their application in marketed products and research.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
Background:
- Oral administration is preferred for patient compliance.
- Multiparticulate systems offer advantages over single-unit dosage forms for uniform drug distribution.
Purpose of the Study:
- To provide a comprehensive overview of pellets in drug delivery.
- To discuss pelletization techniques, characterization, and applications in controlled and sustained release formulations.
Main Methods:
- Literature review focusing on pellets for oral drug delivery.
- Analysis of various pelletization techniques and characterization methods.
- Examination of drug and excipient roles in pellet formulation.
Main Results:
- Pellets offer improved drug distribution and potential for controlled/sustained release.
- Various techniques exist for pellet formation, each with specific merits and demerits.
- Key considerations include drug properties, excipients, and formulation design.
Conclusions:
- Pellets are a versatile dosage form for enhancing oral drug delivery.
- Understanding pelletization and characterization is crucial for developing effective controlled and sustained release formulations.
- The review emphasizes the significance of pellets in current pharmaceutical research and marketed products.
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