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Dynamic Contrast Enhancement (DCE) MRI-Derived Renal Perfusion and Filtration: Basic Concepts
Michael Pedersen1, Pietro Irrera2, Walter Dastrù3
1Department of Clinical Medicine - Comparative Medicine Lab, Aarhus University, Aarhus, Denmark.
Methods in Molecular Biology (Clifton, N.J.)
|January 21, 2021
Summary
Dynamic contrast-enhanced MRI (DCE-MRI) visualizes kidney function by tracking contrast agent transit. This technique aids in diagnosing renal conditions and assessing treatment effectiveness in preclinical models.
Area of Science:
- Nephrology
- Radiology
- Medical Imaging
Background:
- Dynamic contrast-enhanced MRI (DCE-MRI) tracks contrast agent (gadolinium chelates) transit through renal structures.
- It assesses renal uptake and excretion, providing insights into kidney function.
Purpose of the Study:
- Introduce renal DCE-MRI and its methods.
- Provide an overview of preclinical applications for measuring renal perfusion and glomerular filtration rate.
- Highlight DCE-MRI's utility in assessing kidney function and treatment response.
Main Methods:
- Optimizing DCE-MRI protocols for whole-kidney coverage, spatial/temporal resolution, and contrast resolution.
- Analyzing time-dependent enhancement of renal tissues.
- Utilizing preclinical animal models for DCE-MRI studies.
Main Results:
- DCE-MRI enables indirect measurement of key parameters like renal blood flow, glomerular filtration rate, and intrarenal blood volumes.
- The technique is valuable for diagnosing renal dysfunction and monitoring treatment or transplant rejection.
- Preclinical studies demonstrate DCE-MRI's capability in measuring renal perfusion and GFR.
Conclusions:
- Renal DCE-MRI is a valuable tool for evaluating kidney function, perfusion, and filtration.
- Despite potential nephrotoxicity in severe renal dysfunction, DCE-MRI offers significant diagnostic and monitoring capabilities.
- This work, supported by COST Action PARENCHIMA, aims to standardize renal MRI biomarkers.
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