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Noninvasive Renal Perfusion Measurement Using Arterial Spin Labeling (ASL) MRI: Basic Concept.
Min-Chi Ku1, María A Fernández-Seara2, Frank Kober3
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Methods in Molecular Biology (Clifton, N.J.)
|January 21, 2021
Summary
Arterial spin labeling (ASL) MRI offers a noninvasive method to measure kidney blood flow. This technique provides key insights into renal function and disease by quantifying regional perfusion in animal models.
Area of Science:
- Nephrology
- Medical Imaging
- Physiology
Background:
- Kidney function relies on regional blood flow distribution between cortex and medulla.
- Renal perfusion is critical for glomerular filtration and overall renal homeostasis.
- Quantifying regional renal perfusion aids in understanding renal physiology and pathology.
Purpose of the Study:
- To introduce the fundamental concepts of Arterial Spin Labeling Magnetic Resonance Imaging (ASL-MRI).
- To highlight ASL-MRI as a noninvasive and reproducible technique for assessing renal perfusion in preclinical research.
- To establish a foundation for subsequent chapters detailing experimental procedures and data analysis within the COST Action PARENCHIMA framework.
Main Methods:
- Focuses on the principles of ASL-MRI for assessing blood flow.
- Emphasizes noninvasive measurement of regional renal perfusion.
- Utilizes ASL-MRI techniques applicable to animal models.
Main Results:
- ASL-MRI enables noninvasive quantification of regional renal perfusion.
- The technique offers reproducibility in measuring renal blood flow.
- This method provides insights into renal function and pathophysiology.
Conclusions:
- ASL-MRI is a valuable tool for studying renal perfusion noninvasively.
- Understanding regional perfusion is crucial for assessing kidney health and disease.
- This work, supported by COST Action PARENCHIMA, aims to standardize renal MRI biomarkers.
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